Bupropion HCl SR Tablets

Bupropion HCl SR (Sustained Release) tablets may assist with depression and seasonal affective disorder (SAD) treatment.^[1] Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI), which increases dopamine and norepinephrine levels in the brain.^[2] This differs from selective serotonin reuptake inhibitors (SSRIs), so bupropion may be an alternative for individuals with poor SSRI response.^[3] Additionally, bupropion may assist with smoking cessation.^[4]

The information below reflects a commonly used dosing approach for this product. It is provided for general information only and is not a dosing recommendation. A prescribing provider may select a different dose, route, frequency, or titration schedule based on the patient’s treatment goals, response, tolerability, medical history, concomitant therapies, and other patient-specific factors.

Take 1 tablet of the prescribed strength by mouth once daily.

Your prescribed amount, strength, frequency, or duration may differ from the common dosing information shown above. Use this medication only as directed on your prescription label, and do not change how you use it unless instructed by your prescribing provider. Contact your provider or pharmacist if you have questions about your individualized directions.

Store this medication at 68°F to 77°F (20°C – 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. Modell JG, Rosenthal NE, Harriett AE, Krishen A, Asgharian A, Foster VJ, Metz A, Rockett CB, Wightman DS. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005 Oct 15;58(8):658-67. doi: 10.1016/j.biopsych.2005.07.021. PMID: 16271314.
2. Huecker MR, Smiley A, Saadabadi A. Bupropion. [Updated 2023 Apr 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470212/
3. Nieuwstraten CE, Dolovich LR. Bupropion versus selective serotonin-reuptake inhibitors for treatment of depression. Ann Pharmacother. 2001 Dec;35(12):1608-13. doi: 10.1345/aph.1A099. PMID: 11793630.
4. Centers for Disease Control and Prevention. (n.d.). How to use bupropion SR. Retrieved from https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/quit-smoking-medications/how-to-use-quit-smoking-medicines/how-to-use-bupropion-sr.html