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Combining PDE5 Inhibitors With Other Ingredients for Men’s Sexual Health

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A red, an orange and a blue oral dissolving tablet; red and white capsules in a clear jar with a silver lid; yellow and white capsules in a clear jar with a silver lid; blue and white capsules in a clear jar with a silver lid; and a pink, a yellow, a green and a blue troche, all displayed over a white background

Sexual health can be complicated, so helping male patients achieve sexual wellness often requires taking an integrative approach. One in three men deal with rapid ejaculation issues,1 and an estimated 1–4% of men have experienced delayed ejaculation,2 to name just a couple issues. With so much of the male population experiencing similar concerns, it’s no surprise that healthcare providers continually seek answers to a combination of problems specific to the individual patient. This is leading some prescribers to consider emerging therapies for comprehensive libido and sexual support that include, but are not limited to, phosphodiesterase type 5 (PDE5) inhibitors. For patient-specific options, these providers are combining a unique variety of ingredients with various PDE5 inhibitors when they formulate treatments for conditions related to sexual health and overall quality of life.

Though FDA-approved treatments for erectile dysfunction exist, there are no commercially available options for rapid ejaculation or delayed ejaculation. Urologists and men’s health practitioners have long used compounding pharmacies to source these options.

Combination Ingredients for Men’s Sexual Health

Prescribers using emerging therapies for male sexual wellness often combine one or more of the following ingredients with PDE5 inhibitors:

  • Apomorphine 
  • Bremelanotide
  • Cabergoline
  • Dapoxetine
  • Dextromethorphan
  • Oxytocin
  • Phentolamine mesylate
  • Testosterone
  • Tramadol

Most prescribers are seeking compounded PDE5 inhibitor medications because they offer an array of strengths, combinations and alternative dosage forms. There are many custom compounded PDE5 inhibitor combinations that results-oriented healthcare providers have developed as part of their integrative approaches to meeting their patients’ specific needs.

Empower Pharmacy offers PDE5 inhibitor combination capsules, oral disintegrating tablets (ODTs) and troches, many of which are listed below. Providers who already work with Empower can talk to their clinic liaison if they are interested in these or other options. Providers who are interested in partnering with Empower can contact us about these products and everything else we can offer their practices and their patients.

Compounded Oral PDE5 Inhibitor Combinations

Sildenafil Combination Products

Tadalafil Combination Products

Vardenafil Combination Products

  • 1. Premature ejaculation. Cleveland Clinic. Accessed July 27, 2022. https://my.clevelandclinic.org/health/diseases/15627-premature-ejaculation
  • 2. Chen J. The pathophysiology of delayed ejaculation. Transl Androl Urol. 2016;5(4):549-562. doi:10.21037/tau.2016.05.03